GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs60843830 | 1 | rs6709534 | chr2:217334 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.56 | 1.05E-26 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9309473 | 1 | rs6710438 | chr2:73820108 | ALMS1P | chr2:73872046-73912692:+ | -0.35 | -5.12 | 4.78E-7 | Metabolite levels |
| BLCA | cis | rs4372836 | 1 | rs6710959 | chr2:28958603 | TRMT61B | chr2:29072690-29093175:- | -0.29 | -5.03 | 7.45E-7 | Body mass index |
| BLCA | cis | rs9309473 | 1 | rs6711033 | chr2:73746643 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 4.99 | 9.15E-7 | Metabolite levels |
| BLCA | cis | rs6715284 | 1 | rs6711127 | chr2:202213515 | PPIL3 | chr2:201735680-201753999:- | -0.44 | -3.88 | 0.000125 | Rheumatoid arthritis |
| BLCA | cis | rs6715284 | 1 | rs6711941 | chr2:202178130 | PPIL3 | chr2:201735680-201753999:- | -0.53 | -5.3 | 1.93E-7 | Rheumatoid arthritis |
| BLCA | cis | rs6715284 | 1 | rs6715284 | chr2:202154397 | PPIL3 | chr2:201735680-201753999:- | -0.45 | -5 | 8.61E-7 | Rheumatoid arthritis |
| BLCA | cis | rs6715284 | 1 | rs6715380 | chr2:202214505 | PPIL3 | chr2:201735680-201753999:- | -0.46 | -4.11 | 4.92E-5 | Rheumatoid arthritis |
| BLCA | cis | rs9309473 | 1 | rs6715819 | chr2:73772309 | ALMS1P | chr2:73872046-73912692:+ | 0.36 | 5.34 | 1.63E-7 | Metabolite levels |
| BLCA | cis | rs7589728 | 1 | rs6720809 | chr2:88528943 | THNSL2 | chr2:88469835-88486145:+ | -0.53 | -5.36 | 1.45E-7 | Plasma clusterin levels |
| BLCA | cis | rs7589728 | 1 | rs6722069 | chr2:88533151 | THNSL2 | chr2:88469835-88486145:+ | -0.56 | -5.77 | 1.61E-8 | Plasma clusterin levels |
| BLCA | cis | rs11976180 | 1 | rs67239267 | chr7:143745116 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.92 | 7.15E-9 | Obesity-related traits |
| BLCA | cis | rs9309473 | 1 | rs6724782 | chr2:73679990 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.82 | 1.23E-8 | Metabolite levels |
| BLCA | cis | rs6430585 | 1 | rs6732236 | chr2:136501509 | DARS | chr2:136664254-136743222:- | 0.27 | 4.48 | 1.01E-5 | Corneal structure |
| BLCA | cis | rs9309473 | 1 | rs6736866 | chr2:73661986 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 4.97 | 1.0E-6 | Metabolite levels |